Livial 2.5mg

Forms and dosages

Livial is supplied as 2.5mg oral tablets in 28- or 84-day packs. The standard dose is 2.5mg once daily, taken at the same time each day with or without food. There is no progestogen-free or estrogen-free interval — tibolone is a daily continuous regimen. Lower-dose 1.25mg tablets are not available in most markets but lower exposure can be achieved by halving the 2.5mg tablet (although the manufacturer does not specifically support this).

Indications

Livial is approved (in countries where licensed) for treatment of moderate-to-severe vasomotor menopausal symptoms and prevention of postmenopausal osteoporosis in women at least 12 months past their last natural menstrual period. According to current European menopause guidelines, Livial is restricted to women under 60 within 10 years of menopause because of stroke risk increases shown in the LIFT trial in older women.