Glucophage 1000mg

Forms and dosages

Glucophage is administered orally with meals to improve gastrointestinal tolerance. According to the prescribing information, treatment usually starts at 500mg once or twice daily and is increased every one to two weeks based on tolerability and response, up to a typical maximum of 2000 to 3000mg per day in divided doses. The extended-release formulation supports once-daily evening dosing. Dose adjustment is needed for moderate to severe renal impairment.

Indications

The medication is indicated as first-line oral therapy in adults with type 2 diabetes mellitus, alone or in combination with other antidiabetic agents, including insulin. In selected paediatric populations and in some markets it is also used in adolescents from 10 years. Off-label or label-extension uses include polycystic ovary syndrome and prediabetes under specialist supervision. According to international guidelines, metformin should be considered at diagnosis in most adults with type 2 diabetes unless contraindicated.