Demadex 20mg

Forms and dosages

Demadex is supplied as oral tablets in 5, 10, 20 and 100mg strengths. For heart-failure oedema, typical dosing is 10–20mg once daily, titrated based on weight and symptom response. For hypertension, 5–10mg daily is sufficient. For chronic kidney disease, higher doses 100–200mg daily may be needed. Take in the morning to limit night-time urination. The dose ratio of torsemide:furosemide is approximately 1:2–4.

Indications

Demadex is approved for oedema in heart failure, hepatic cirrhosis or chronic kidney disease, and for hypertension at low doses. According to recent heart-failure guidelines, torsemide may be preferred over furosemide for chronic heart-failure management because of its more reliable absorption and the TRANSFORM-HF trial findings, although that trial showed no clear mortality benefit between the two agents.