Celebrex with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Celebrex (Celecoxib). Most antibiotics do not interfere meaningfully with Celecoxib at 50mg, 100mg, 200mg, 400mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Pain Relief Medications agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Celecoxib at 50mg, 100mg, 200mg, 400mg.
Practical guidance
According to the prescribing information for Celecoxib, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Celebrex is co-administered. Adjusted 50mg, 100mg, 200mg, 400mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Celebrex during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Celecoxib is metabolised and may need a temporary 50mg, 100mg, 200mg, 400mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Celebrex regimen.
Will antibiotics make Celebrex stop working? ▾
Most antibiotics do not affect Celebrex efficacy. Rifampicin and a few others can lower Celecoxib levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
More on Celebrex
- With alcoholCelebrex and alcohol — is it safe to drink?
- With foodShould Celebrex be taken with food?
- Side effectsCelebrex side effects: common, rare and warning signs
- Dosage guideCelebrex dosage guide: how much to take and when
- OnsetHow fast does Celebrex start working?
- DurationHow long does Celebrex last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.