Celebrex 200mg

Forms and dosages

Celebrex is administered orally once or twice daily with or without food. According to the prescribing information, the usual dose is 200mg once daily for osteoarthritis, 100-200mg twice daily for rheumatoid arthritis and ankylosing spondylitis, and 400mg loading followed by 200mg twice daily for acute pain. Doses should be reduced in moderate hepatic impairment and in CYP2C9 poor metabolisers.

Indications

Celebrex is approved in adults for the treatment of osteoarthritis, rheumatoid arthritis, juvenile idiopathic arthritis (in some markets), ankylosing spondylitis, primary dysmenorrhoea and acute pain. According to clinical guidelines, COX-2 selective NSAIDs are particularly useful in patients with high gastrointestinal risk who require NSAID therapy, often combined with acid suppression. Cardiovascular risk should be carefully assessed before initiation.