Augmentin with statins (atorvastatin, rosuvastatin, simvastatin)
Statins are among the most widely prescribed chronic medications, often used alongside many other agents including Augmentin (Amoxicillin/Clavulanate). The combination at 500/125mg, 875/125mg, 1000/62.5mg is generally safe, but a small number of statin-specific interactions matter — particularly for simvastatin, which shares CYP3A4 metabolism with several common medications.
How Augmentin interacts with statins
Statins differ in their metabolic pathways: simvastatin and atorvastatin go through CYP3A4 most heavily; rosuvastatin and pravastatin take other routes and have fewer drug interactions. If Amoxicillin, Clavulanate acts on CYP3A4, the combination with simvastatin or atorvastatin can raise statin levels and increase muscle-related side effects. Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), but is hydrolysed by beta-lactamase enzymes produced by some resistant bacteria.
Practical guidance
According to the prescribing information for Amoxicillin, Clavulanate, anyone on a statin should mention it before starting Augmentin at 500/125mg, 875/125mg, 1000/62.5mg. The prescriber may switch the statin (e.g. from simvastatin to rosuvastatin) or adjust the statin dose during Augmentin use. Persistent muscle pain, weakness or dark urine on the combination warrants prompt evaluation.
Frequently asked questions
Can I take Augmentin with my statin? ▾
For most users at 500/125mg, 875/125mg, 1000/62.5mg, yes — particularly with rosuvastatin or pravastatin which have minimal interactions with Amoxicillin, Clavulanate. Simvastatin and atorvastatin combinations may need a dose review by the prescriber to avoid amplified statin effects.
Will Augmentin cause muscle pain with my statin? ▾
Muscle pain is the most common statin side effect and can be amplified when combined with medications that raise statin plasma levels. Persistent or new muscle pain on Augmentin at 500/125mg, 875/125mg, 1000/62.5mg should be reported promptly so the prescriber can review the combination.
More on Augmentin
- With alcoholAugmentin and alcohol — is it safe to drink?
- With foodShould Augmentin be taken with food?
- Side effectsAugmentin side effects: common, rare and warning signs
- Dosage guideAugmentin dosage guide: how much to take and when
- OnsetHow fast does Augmentin start working?
- DurationHow long does Augmentin last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.