Addyi and cannabis (marijuana, THC)
As cannabis becomes legal or decriminalised in more jurisdictions, the practical question of combining it with prescription medication comes up regularly. Addyi (Flibanserin) and cannabis share several pharmacological pathways, and the combination at 100mg is not automatically benign even where both are legal.
How cannabis affects Addyi
THC and other cannabinoids are metabolised partly by hepatic CYP enzymes, including CYP3A4 — the same pathway used by many Women's Sexual Health medications. Frequent cannabis use can shift the metabolism of Flibanserin mildly. THC also has cardiovascular effects (increased heart rate, blood pressure changes) and central nervous system effects that can stack with Addyi's side-effect profile.
Practical guidance
Occasional moderate cannabis use is unlikely to cause clinically meaningful problems for most adults on Addyi at 100mg. Heavy daily use, edibles with high THC content, or cannabis combined with alcohol substantially raise the risk of dizziness, hypotension, impaired judgement and amplified side effects from Flibanserin. According to the prescribing information, the full list of recreational substances should be disclosed to the prescriber.
Frequently asked questions
Can I use cannabis while taking Addyi? ▾
For most adults at 100mg, occasional moderate cannabis is tolerated, but heavy daily use is not advised because of metabolic and additive cardiovascular effects with Flibanserin. The safe practice is to mention it to the prescriber.
Does CBD interact with Addyi? ▾
CBD inhibits several CYP enzymes including CYP3A4, which can raise plasma levels of medications that go through that pathway. For Addyi specifically, this depends on whether Flibanserin uses CYP3A4. Daily high-dose CBD products warrant a pharmacist check.
More on Addyi
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