Stendra vs Valtrex: side-by-side comparison
Stendra (Erectile Dysfunction (ED)) and Valtrex (Antiviral Medications) belong to different therapeutic classes and are rarely interchangeable. This page compares the medications' purposes, mechanisms and the situations where each is used.
| Property | Stendra | Valtrex |
|---|---|---|
| Active ingredient | Avanafil | Valacyclovir |
| Manufacturer | Metuchen Pharmaceuticals | GlaxoSmithKline |
| Class | Erectile Dysfunction (ED) | Antiviral Medications |
| Strengths | 50mg, 100mg, 200mg | 500mg, 1000mg |
| Forms | tablet | tablet |
What's the same
Stendra and Valtrex are used in very different patients, and the points in common are limited. The main shared element is that both meet regulatory standards for efficacy and safety and benefit from pharmacist oversight.
Key differences
Stendra belongs to Erectile Dysfunction (ED) while Valtrex belongs to Antiviral Medications. Indications, mechanisms and target populations differ. The comparison is most useful when a clinician has mentioned both medications and the patient wants to understand where each fits.
Mechanism and action
Stendra: Avanafil selectively inhibits phosphodiesterase type 5 (PDE5) in the corpus cavernosum, increasing cGMP and enhancing nitric-oxide-mediated vasodilation in response to sexual stimulation. Valtrex: Valacyclovir is rapidly and almost completely converted to acyclovir during first-pass intestinal and hepatic metabolism by valacyclovir hydrolase.
When Stendra is preferred
Stendra is approved for erectile dysfunction in adult men.
When Valtrex is preferred
Valtrex is approved in adults for the treatment of herpes simplex virus infections, including genital herpes (initial episodes, recurrent episodes and suppressive therapy), herpes labialis (single-day high-dose regimen), reduction of transmission in heterosexual immunocompetent a…
Frequently asked questions
Is Stendra or Valtrex better? ▾
Stendra and Valtrex are not interchangeable — they treat different conditions. Asking which is "better" is meaningful only when a clinician has weighed both for the same specific clinical scenario.
Can I switch from Stendra to Valtrex? ▾
Switching between Stendra and Valtrex is rarely an appropriate decision since they belong to different classes and treat different conditions. The real question is usually whether the diagnosis calls for one medication or the other — which the prescriber resolves.
Do Stendra and Valtrex have the same side effects? ▾
No — they belong to different classes and have distinct side-effect profiles. Each medication has its own prescribing information.
More Stendra comparisons
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.