Stendra vs Levitra: side-by-side comparison
Stendra (Avanafil) and Levitra (Vardenafil) both belong to the Erectile Dysfunction (ED) class. They share clinical context but use different active ingredients. The choice between them depends on mechanism nuances, side-effect profile and individual response.
| Property | Stendra | Levitra |
|---|---|---|
| Active ingredient | Avanafil | Vardenafil |
| Manufacturer | Metuchen Pharmaceuticals | Bayer |
| Class | Erectile Dysfunction (ED) | Erectile Dysfunction (ED) |
| Strengths | 50mg, 100mg, 200mg | 5mg, 10mg, 20mg |
| Forms | tablet | tablet |
What's the same
Stendra and Levitra both belong to the Erectile Dysfunction (ED) class and are used for partially overlapping indications. The active ingredients — Avanafil vs Vardenafil — share the same therapeutic approach, so many safety and management points carry across both.
Key differences
Meaningful differences are in active ingredient (Avanafil vs Vardenafil), strengths (50mg, 100mg, 200mg vs 5mg, 10mg, 20mg), forms (tablet vs tablet), and the mechanism, half-life and side-effect nuances that distinguish members of the class.
Mechanism and action
Stendra: Avanafil selectively inhibits phosphodiesterase type 5 (PDE5) in the corpus cavernosum, increasing cGMP and enhancing nitric-oxide-mediated vasodilation in response to sexual stimulation. Levitra: During sexual stimulation, nitric oxide is released in the corpus cavernosum and activates an enzyme that produces cyclic GMP, which relaxes smooth muscle and increases blood flow to support erection.
When Stendra is preferred
Stendra is approved for erectile dysfunction in adult men.
When Levitra is preferred
Levitra is indicated in adult men for the treatment of erectile dysfunction.
Frequently asked questions
Is Stendra or Levitra better? ▾
There is no single answer. Stendra and Levitra both belong to the Erectile Dysfunction (ED) class but differ in mechanism nuances, half-life and side-effect profile. Preference depends on the patient, the prescriber and prior response to other therapies.
Can I switch from Stendra to Levitra? ▾
Switching within the Erectile Dysfunction (ED) class is done under supervision, typically using equivalent doses and a follow-up period to confirm response and tolerance. It is not a self-directed decision.
Do Stendra and Levitra have the same side effects? ▾
They share many of the Erectile Dysfunction (ED) class side effects, with differences from mechanism and dose. Each medication's prescribing information lists specifics.
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The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.