Sildenafil Citrate vs Avanafil: side-by-side comparison
Sildenafil Citrate (PDE5 inhibitor) and Avanafil (Phosphodiesterase type 5 (PDE5) inhibitor) belong to different therapeutic classes and are rarely substitutes for each other. The comparison is useful when a single patient is weighing both options for adjacent or overlapping needs.
| Property | Sildenafil Citrate | Avanafil |
|---|---|---|
| Therapeutic class | PDE5 inhibitor | Phosphodiesterase type 5 (PDE5) inhibitor |
| CAS | 171599-83-0 | 330784-47-9 |
| ATC | G04BE03 | G04BE10 |
| Molecular weight | 666.7 g/mol | 483.95 g/mol |
| Brands with this active ingredient | 10 | 1 |
What they share
Sildenafil Citrate and Avanafil share the common regulatory framework for prescription active ingredients, bioequivalence standards for generics, and pharmacist oversight. Beyond that, points in common are limited.
Key differences
Sildenafil Citrate acts by a different mechanism than Avanafil, with indications that barely overlap. Comparing the two is useful when a clinician has mentioned both in the same context or the patient wants to understand why one was prescribed instead of the other.
Mechanisms compared
Sildenafil Citrate: Sildenafil citrate selectively inhibits phosphodiesterase type 5 (PDE5), an enzyme that breaks down cyclic guanosine monophosphate in the corpus cavernosum. Avanafil: Avanafil selectively inhibits phosphodiesterase type 5 (PDE5) in the corpus cavernosum, increasing cGMP and enhancing nitric-oxide-mediated vasodilation in response to sexual stimulation.
Indications compared
Sildenafil Citrate: Sildenafil citrate is approved in adult men for the treatment of erectile dysfunction. Avanafil: Avanafil is approved for erectile dysfunction in adult men.
Safety profile
Sildenafil Citrate: Common adverse effects reported in clinical trials include headache, facial flushing, nasal congestion, dyspepsia and transient visual disturbances. Avanafil: The most common adverse effects are headache, flushing, nasal congestion and back pain — typical of the PDE5 class but generally less frequent than with older agents.
Frequently asked questions
Is Sildenafil Citrate better than Avanafil? ▾
Sildenafil Citrate and Avanafil are not "better or worse" — they treat different things. The sensible question is which fits your specific need.
Can Sildenafil Citrate and Avanafil be combined? ▾
Whether they can be combined depends on the indications and the interaction profile of each. If both are in a single prescription, the prescriber has weighed it; in self-medication they should never be combined.
Do they have the same side-effect profile? ▾
No — they belong to different classes and have distinct side-effect profiles. Each has its own prescribing information.
Products with Sildenafil Citrate
Products with Avanafil
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.