Drospirenone vs Clomiphene: side-by-side comparison
Drospirenone (Progestogen with anti-mineralocorticoid and anti-androgen activity) and Clomiphene (Selective estrogen receptor modulator (ovulation induction)) belong to different therapeutic classes and are rarely substitutes for each other. The comparison is useful when a single patient is weighing both options for adjacent or overlapping needs.
| Property | Drospirenone | Clomiphene |
|---|---|---|
| Therapeutic class | Progestogen with anti-mineralocorticoid and anti-androgen activity | Selective estrogen receptor modulator (ovulation induction) |
| CAS | 67392-87-4 | 911-45-5 |
| ATC | G03AA12 | G03GB02 |
| Molecular weight | 366.49 g/mol | 405.96 g/mol |
| Brands with this active ingredient | 2 | 1 |
What they share
Drospirenone and Clomiphene share the common regulatory framework for prescription active ingredients, bioequivalence standards for generics, and pharmacist oversight. Beyond that, points in common are limited.
Key differences
Drospirenone acts by a different mechanism than Clomiphene, with indications that barely overlap. Comparing the two is useful when a clinician has mentioned both in the same context or the patient wants to understand why one was prescribed instead of the other.
Mechanisms compared
Drospirenone: Drospirenone activates progesterone receptors to suppress ovulation and produce the contraceptive effect when combined with an estrogen. Clomiphene: Clomiphene acts as a competitive antagonist of estrogen receptors at the hypothalamus, blocking the negative feedback that estrogen normally exerts on hypothalamic gonadotropin-releasing hormone production.
Indications compared
Drospirenone: Drospirenone in combination with ethinylestradiol is approved as combined oral contraception, treatment of moderate acne in women requesting contraception, and treatment of premenstrual dysphoric disorder. Clomiphene: Clomiphene is approved for the treatment of anovulatory infertility in women with intact pituitary-ovarian function — particularly polycystic ovary syndrome (PCOS) — when other causes of infertility have been excluded or…
Safety profile
Drospirenone: Common adverse effects include menstrual irregularities, breast tenderness, headache, mood changes and nausea, mostly in the first 2–3 cycles. Clomiphene: Common adverse effects include hot flashes, mood swings, breast tenderness, ovarian enlargement and visual disturbances (typically reversible on discontinuation).
Frequently asked questions
Is Drospirenone better than Clomiphene? ▾
Drospirenone and Clomiphene are not "better or worse" — they treat different things. The sensible question is which fits your specific need.
Can Drospirenone and Clomiphene be combined? ▾
Whether they can be combined depends on the indications and the interaction profile of each. If both are in a single prescription, the prescriber has weighed it; in self-medication they should never be combined.
Do they have the same side-effect profile? ▾
No — they belong to different classes and have distinct side-effect profiles. Each has its own prescribing information.
Products with Drospirenone
Products with Clomiphene
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.