Synthroid vs Lexapro: side-by-side comparison
Synthroid (Hormone und Empfängnisverhütung) and Lexapro (Antidepressiva) belong to different therapeutic classes and are rarely interchangeable. This page compares the medications' purposes, mechanisms and the situations where each is used.
| Property | Synthroid | Lexapro |
|---|---|---|
| Active ingredient | Levothyroxine | Escitalopram |
| Manufacturer | AbbVie | Forest/Allergan |
| Class | Hormone und Empfängnisverhütung | Antidepressiva |
| Strengths | 25mcg, 50mcg, 75mcg, 100mcg, 150mcg | 5mg, 10mg, 20mg |
| Forms | tablet | tablet |
What's the same
Synthroid and Lexapro are used in very different patients, and the points in common are limited. The main shared element is that both meet regulatory standards for efficacy and safety and benefit from pharmacist oversight.
Key differences
Synthroid belongs to Hormone und Empfängnisverhütung while Lexapro belongs to Antidepressiva. Indications, mechanisms and target populations differ. The comparison is most useful when a clinician has mentioned both medications and the patient wants to understand where each fits.
Mechanism and action
Synthroid: Levothyroxin ersetzt das defizitäre endogene Thyroxin, das in den Geweben durch Deiodinasen in das aktive Hormon Trijodthyronin (T3) umgewandelt wird. Lexapro: Lexapro wirkt durch selektive Hemmung des Serotonin-Wiederaufnahmetransporters (SERT) an der Synapse und erhöht so die Verfügbarkeit von Serotonin für postsynaptische Rezeptoren.
When Synthroid is preferred
Synthroid ist zur Behandlung der Hypothyreose jeglicher Ursache (Hashimoto-Thyreoiditis, nach Thyreoidektomie, nach Radioiodtherapie, kongenital), bei Struma sowie zur TSH-Suppression nach differenziertem Schilddrüsenkarzinom zugelassen.
When Lexapro is preferred
Lexapro ist bei Erwachsenen und Jugendlichen ab 12 Jahren (Depression) sowie bei Erwachsenen (generalisierte Angststörung) zur Behandlung von Major Depression und generalisierter Angststörung zugelassen.
Häufig gestellte Fragen
Is Synthroid or Lexapro better? ▾
Synthroid and Lexapro are not interchangeable — they treat different conditions. Asking which is "better" is meaningful only when a clinician has weighed both for the same specific clinical scenario.
Can I switch from Synthroid to Lexapro? ▾
Switching between Synthroid and Lexapro is rarely an appropriate decision since they belong to different classes and treat different conditions. The real question is usually whether the diagnosis calls for one medication or the other — which the prescriber resolves.
Do Synthroid and Lexapro have the same side effects? ▾
No — they belong to different classes and have distinct side-effect profiles. Each medication has its own prescribing information.
More Synthroid comparisons
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