Sertraline vs Celexa: side-by-side comparison
Sertraline (Sertraline) and Celexa (Citalopram) both belong to the Antidepressiva class. They share clinical context but use different active ingredients. The choice between them depends on mechanism nuances, side-effect profile and individual response.
| Property | Sertraline | Celexa |
|---|---|---|
| Active ingredient | Sertraline | Citalopram |
| Manufacturer | Various generics | Forest Laboratories / AbbVie |
| Class | Antidepressiva | Antidepressiva |
| Strengths | 25mg, 50mg, 100mg | 10mg, 20mg, 40mg |
| Forms | tablet | tablet |
What's the same
Sertraline and Celexa both belong to the Antidepressiva class and are used for partially overlapping indications. The active ingredients — Sertraline vs Citalopram — share the same therapeutic approach, so many safety and management points carry across both.
Key differences
Meaningful differences are in active ingredient (Sertraline vs Citalopram), strengths (25mg, 50mg, 100mg vs 10mg, 20mg, 40mg), forms (tablet vs tablet), and the mechanism, half-life and side-effect nuances that distinguish members of the class.
Mechanism and action
Sertraline: Sertralin blockiert selektiv den Serotonintransporter am präsynaptischen Neuron und verhindert so die Wiederaufnahme von Serotonin aus dem synaptischen Spalt. Celexa: Citalopram hemmt selektiv den Serotonin-Reuptake-Transporter und erhöht damit die synaptische Serotoninverfügbarkeit, mit nur begrenzter Affinität zu Noradrenalin-Transportern oder anderen Rezeptoren.
When Sertraline is preferred
Generisches Sertralin teilt die Anwendungsgebiete des Originalpräparats: Major Depression, Panikstörung, Zwangsstörung, posttraumatische Belastungsstörung, soziale Angststörung und prämenstruelle dysphorische Störung, jeweils bei Erwachsenen.
When Celexa is preferred
Celexa ist zugelassen zur Behandlung der Major Depression.
Häufig gestellte Fragen
Is Sertraline or Celexa better? ▾
There is no single answer. Sertraline and Celexa both belong to the Antidepressiva class but differ in mechanism nuances, half-life and side-effect profile. Preference depends on the patient, the prescriber and prior response to other therapies.
Can I switch from Sertraline to Celexa? ▾
Switching within the Antidepressiva class is done under supervision, typically using equivalent doses and a follow-up period to confirm response and tolerance. It is not a self-directed decision.
Do Sertraline and Celexa have the same side effects? ▾
They share many of the Antidepressiva class side effects, with differences from mechanism and dose. Each medication's prescribing information lists specifics.
More Sertraline comparisons
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