Lyrica vs Voltaren: side-by-side comparison
Lyrica (Pregabalin) and Voltaren (Diclofenac) both belong to the Schmerzmedikamente class. They share clinical context but use different active ingredients. The choice between them depends on mechanism nuances, side-effect profile and individual response.
| Property | Lyrica | Voltaren |
|---|---|---|
| Active ingredient | Pregabalin | Diclofenac |
| Manufacturer | Pfizer | Novartis |
| Class | Schmerzmedikamente | Schmerzmedikamente |
| Strengths | 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, 300mg | 25mg, 50mg, 75mg, 100mg |
| Forms | capsule, oral solution, extended-release tablet | tablet, delayed-release tablet, topical gel, suppository |
What's the same
Lyrica and Voltaren both belong to the Schmerzmedikamente class and are used for partially overlapping indications. The active ingredients — Pregabalin vs Diclofenac — share the same therapeutic approach, so many safety and management points carry across both.
Key differences
Meaningful differences are in active ingredient (Pregabalin vs Diclofenac), strengths (25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, 300mg vs 25mg, 50mg, 75mg, 100mg), forms (capsule, oral solution, extended-release tablet vs tablet, delayed-release tablet, topical gel, suppository), and the mechanism, half-life and side-effect nuances that distinguish members of the class.
Mechanism and action
Lyrica: Pregabalin bindet an die Alpha-2-Delta-Untereinheit spannungsabhängiger Calciumkanäle im Zentralnervensystem, wodurch der präsynaptische Calciumeinstrom und die Freisetzung exzitatorischer Neurotransmitter wie Glutamat… Voltaren: Diclofenac hemmt reversibel die Cyclooxygenase-Enzyme COX-1 und COX-2, mit etwas stärkerer Selektivität für COX-2 als Ibuprofen und Naproxen.
When Lyrica is preferred
Lyrica ist bei Erwachsenen zugelassen zur Behandlung neuropathischer Schmerzen bei diabetischer peripherer Neuropathie, postherpetischer Neuralgie, Rückenmarkverletzungen und anderen Formen zentraler neuropathischer Schmerzen (in einigen Ländern), zur Behandlung der generalisiert…
When Voltaren is preferred
Voltaren ist bei Erwachsenen zur Behandlung von Arthrose, rheumatoider Arthritis, ankylosierender Spondylitis, akuten muskuloskelettalen Schmerzen, postoperativen Schmerzen, primärer Dysmenorrhoe, akuter Migräne und Ureterkolik zugelassen.
Häufig gestellte Fragen
Is Lyrica or Voltaren better? ▾
There is no single answer. Lyrica and Voltaren both belong to the Schmerzmedikamente class but differ in mechanism nuances, half-life and side-effect profile. Preference depends on the patient, the prescriber and prior response to other therapies.
Can I switch from Lyrica to Voltaren? ▾
Switching within the Schmerzmedikamente class is done under supervision, typically using equivalent doses and a follow-up period to confirm response and tolerance. It is not a self-directed decision.
Do Lyrica and Voltaren have the same side effects? ▾
They share many of the Schmerzmedikamente class side effects, with differences from mechanism and dose. Each medication's prescribing information lists specifics.
More Lyrica comparisons
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