Dutasteride vs Medroxyprogesterone: side-by-side comparison
Dutasteride (Dual 5α-reductase inhibitor (type 1 and type 2)) and Medroxyprogesterone (Progestin) belong to different therapeutic classes and are rarely substitutes for each other. The comparison is useful when a single patient is weighing both options for adjacent or overlapping needs.
| Property | Dutasteride | Medroxyprogesterone |
|---|---|---|
| Therapeutic class | Dual 5α-reductase inhibitor (type 1 and type 2) | Progestin |
| CAS | 164656-23-9 | 520-85-4 |
| ATC | G04CB02 | G03DA02 |
| Molecular weight | 528.53 g/mol | 344.49 g/mol |
| Brands with this active ingredient | 1 | 1 |
What they share
Dutasteride and Medroxyprogesterone share the common regulatory framework for prescription active ingredients, bioequivalence standards for generics, and pharmacist oversight. Beyond that, points in common are limited.
Key differences
Dutasteride acts by a different mechanism than Medroxyprogesterone, with indications that barely overlap. Comparing the two is useful when a clinician has mentioned both in the same context or the patient wants to understand why one was prescribed instead of the other.
Mechanisms compared
Dutasteride: Dutasterid hemmt irreversibel beide Isoenzyme der 5α-Reduktase, des Enzyms, das Testosteron zu Dihydrotestosteron (DHT) umwandelt. Medroxyprogesterone: MPA bindet an Progesteronrezeptoren und entfaltet starke gestagene Wirkungen: Verdickung des Zervixschleims, Hemmung der Ovulation, Verdünnung des Endometriums und Verringerung von Hitzewallungen.
Indications compared
Dutasteride: Dutasterid ist zugelassen bei symptomatischer benigner Prostatahyperplasie, allein oder in Kombination mit Tamsulosin (Combodart/Jalyn) zur stärkeren Symptomlinderung. Medroxyprogesterone: MPA ist zugelassen bei Amenorrhoe, abnormalen Uterusblutungen aufgrund hormoneller Dysbalancen, zur Vorbeugung einer Endometriumhyperplasie bei postmenopausalen Frauen unter Östrogentherapie sowie zur Schwangerschaftsver…
Safety profile
Dutasteride: Häufige Nebenwirkungen sind sexuelle Funktionsstörungen (verminderte Libido, erektile Dysfunktion, Ejakulationsstörungen), Gynäkomastie und Brustspannen. Medroxyprogesterone: Häufige Nebenwirkungen von oralem MPA sind unregelmäßige Blutungen, Brustspannen, Stimmungsschwankungen, Flüssigkeitsretention und Gewichtszunahme.
Häufig gestellte Fragen
Is Dutasteride better than Medroxyprogesterone? ▾
Dutasteride and Medroxyprogesterone are not "better or worse" — they treat different things. The sensible question is which fits your specific need.
Can Dutasteride and Medroxyprogesterone be combined? ▾
Whether they can be combined depends on the indications and the interaction profile of each. If both are in a single prescription, the prescriber has weighed it; in self-medication they should never be combined.
Do they have the same side-effect profile? ▾
No — they belong to different classes and have distinct side-effect profiles. Each has its own prescribing information.
Products with Dutasteride
Products with Medroxyprogesterone
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