Dutasteride vs Amiloride: side-by-side comparison
Dutasteride (Dual 5α-reductase inhibitor (type 1 and type 2)) and Amiloride (Potassium-sparing diuretic) belong to different therapeutic classes and are rarely substitutes for each other. The comparison is useful when a single patient is weighing both options for adjacent or overlapping needs.
| Property | Dutasteride | Amiloride |
|---|---|---|
| Therapeutic class | Dual 5α-reductase inhibitor (type 1 and type 2) | Potassium-sparing diuretic |
| CAS | 164656-23-9 | 2609-46-3 |
| ATC | G04CB02 | C03DB01 |
| Molecular weight | 528.53 g/mol | 229.63 g/mol |
| Brands with this active ingredient | 1 | 1 |
What they share
Dutasteride and Amiloride share the common regulatory framework for prescription active ingredients, bioequivalence standards for generics, and pharmacist oversight. Beyond that, points in common are limited.
Key differences
Dutasteride acts by a different mechanism than Amiloride, with indications that barely overlap. Comparing the two is useful when a clinician has mentioned both in the same context or the patient wants to understand why one was prescribed instead of the other.
Mechanisms compared
Dutasteride: Dutasterid hemmt irreversibel beide Isoenzyme der 5α-Reduktase, des Enzyms, das Testosteron zu Dihydrotestosteron (DHT) umwandelt. Amiloride: Amilorid blockiert den epithelialen Natriumkanal (ENaC) im distalen Konvolut und im Sammelrohr der Niere und reduziert die Natriumrückresorption sowie indirekt die Ausscheidung von Kalium- und Wasserstoffionen.
Indications compared
Dutasteride: Dutasterid ist zugelassen bei symptomatischer benigner Prostatahyperplasie, allein oder in Kombination mit Tamsulosin (Combodart/Jalyn) zur stärkeren Symptomlinderung. Amiloride: Amilorid ist zur Behandlung der Hypertonie (typischerweise in Kombination mit Thiaziden), der Ödeme bei Herzinsuffizienz oder Leberzirrhose (in Kombination) und des primären Hyperaldosteronismus (Liddle-Syndrom und Pseud…
Safety profile
Dutasteride: Häufige Nebenwirkungen sind sexuelle Funktionsstörungen (verminderte Libido, erektile Dysfunktion, Ejakulationsstörungen), Gynäkomastie und Brustspannen. Amiloride: Häufige Nebenwirkungen sind Hyperkaliämie (das Hauptrisiko), Hyponatriämie, Dehydratation und Magen-Darm-Beschwerden.
Häufig gestellte Fragen
Is Dutasteride better than Amiloride? ▾
Dutasteride and Amiloride are not "better or worse" — they treat different things. The sensible question is which fits your specific need.
Can Dutasteride and Amiloride be combined? ▾
Whether they can be combined depends on the indications and the interaction profile of each. If both are in a single prescription, the prescriber has weighed it; in self-medication they should never be combined.
Do they have the same side-effect profile? ▾
No — they belong to different classes and have distinct side-effect profiles. Each has its own prescribing information.
Products with Dutasteride
Products with Amiloride
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