Amlodipine vs Vardenafil: side-by-side comparison
Amlodipine (Dihydropyridine calcium-channel blocker) and Vardenafil (PDE5 inhibitor) belong to different therapeutic classes and are rarely substitutes for each other. The comparison is useful when a single patient is weighing both options for adjacent or overlapping needs.
| Property | Amlodipine | Vardenafil |
|---|---|---|
| Therapeutic class | Dihydropyridine calcium-channel blocker | PDE5 inhibitor |
| CAS | 88150-42-9 | 224785-91-5 |
| ATC | C08CA01 | G04BE09 |
| Molecular weight | 408.88 g/mol | 488.6 g/mol |
| Brands with this active ingredient | 1 | 2 |
What they share
Amlodipine and Vardenafil share the common regulatory framework for prescription active ingredients, bioequivalence standards for generics, and pharmacist oversight. Beyond that, points in common are limited.
Key differences
Amlodipine acts by a different mechanism than Vardenafil, with indications that barely overlap. Comparing the two is useful when a clinician has mentioned both in the same context or the patient wants to understand why one was prescribed instead of the other.
Mechanisms compared
Amlodipine: Amlodipin blockiert selektiv L-Typ-Calciumkanäle in der glatten Gefäßmuskulatur, vermindert den transmembranen Calciumeinstrom und führt zu einer peripheren arteriellen Vasodilatation. Vardenafil: Vardenafil hemmt selektiv die PDE5, das Enzym, das zyklisches Guanosinmonophosphat im Corpus cavernosum abbaut.
Indications compared
Amlodipine: Amlodipin ist bei Erwachsenen zur Behandlung der essentiellen arteriellen Hypertonie und der chronisch stabilen Angina pectoris sowie der vasospastischen (Prinzmetal-)Angina zugelassen. Vardenafil: Vardenafil ist bei erwachsenen Männern zur Behandlung der erektilen Dysfunktion zugelassen.
Safety profile
Amlodipine: Häufige Nebenwirkungen sind periphere Ödeme (typischerweise an den Knöcheln), Flush, Kopfschmerzen, Palpitationen und Müdigkeit; die meisten sind dosisabhängig. Vardenafil: Häufige Nebenwirkungen in klinischen Studien sind Kopfschmerzen, Gesichtsrötung, verstopfte Nase, Dyspepsie und Schwindel.
Häufig gestellte Fragen
Is Amlodipine better than Vardenafil? ▾
Amlodipine and Vardenafil are not "better or worse" — they treat different things. The sensible question is which fits your specific need.
Can Amlodipine and Vardenafil be combined? ▾
Whether they can be combined depends on the indications and the interaction profile of each. If both are in a single prescription, the prescriber has weighed it; in self-medication they should never be combined.
Do they have the same side-effect profile? ▾
No — they belong to different classes and have distinct side-effect profiles. Each has its own prescribing information.
Products with Amlodipine
Products with Vardenafil
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