Celexa vs Lyrica: side-by-side comparison
Celexa (Antidepressiva) and Lyrica (Schmerzmedikamente) belong to different therapeutic classes and are rarely interchangeable. This page compares the medications' purposes, mechanisms and the situations where each is used.
| Property | Celexa | Lyrica |
|---|---|---|
| Active ingredient | Citalopram | Pregabalin |
| Manufacturer | Forest Laboratories / AbbVie | Pfizer |
| Class | Antidepressiva | Schmerzmedikamente |
| Strengths | 10mg, 20mg, 40mg | 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, 300mg |
| Forms | tablet | capsule, oral solution, extended-release tablet |
What's the same
Celexa and Lyrica are used in very different patients, and the points in common are limited. The main shared element is that both meet regulatory standards for efficacy and safety and benefit from pharmacist oversight.
Key differences
Celexa belongs to Antidepressiva while Lyrica belongs to Schmerzmedikamente. Indications, mechanisms and target populations differ. The comparison is most useful when a clinician has mentioned both medications and the patient wants to understand where each fits.
Mechanism and action
Celexa: Citalopram hemmt selektiv den Serotonin-Reuptake-Transporter und erhöht damit die synaptische Serotoninverfügbarkeit, mit nur begrenzter Affinität zu Noradrenalin-Transportern oder anderen Rezeptoren. Lyrica: Pregabalin bindet an die Alpha-2-Delta-Untereinheit spannungsabhängiger Calciumkanäle im Zentralnervensystem, wodurch der präsynaptische Calciumeinstrom und die Freisetzung exzitatorischer Neurotransmitter wie Glutamat…
When Celexa is preferred
Celexa ist zugelassen zur Behandlung der Major Depression.
When Lyrica is preferred
Lyrica ist bei Erwachsenen zugelassen zur Behandlung neuropathischer Schmerzen bei diabetischer peripherer Neuropathie, postherpetischer Neuralgie, Rückenmarkverletzungen und anderen Formen zentraler neuropathischer Schmerzen (in einigen Ländern), zur Behandlung der generalisiert…
Häufig gestellte Fragen
Is Celexa or Lyrica better? ▾
Celexa and Lyrica are not interchangeable — they treat different conditions. Asking which is "better" is meaningful only when a clinician has weighed both for the same specific clinical scenario.
Can I switch from Celexa to Lyrica? ▾
Switching between Celexa and Lyrica is rarely an appropriate decision since they belong to different classes and treat different conditions. The real question is usually whether the diagnosis calls for one medication or the other — which the prescriber resolves.
Do Celexa and Lyrica have the same side effects? ▾
No — they belong to different classes and have distinct side-effect profiles. Each medication has its own prescribing information.
More Celexa comparisons
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